Table 1.
Significant fold changes of expression of genes involved in cell proliferation, cell cycle regulation and DNA replication by knockdown of WT1 or p63 in FaDu cells
| Term | Gene name | Expected effect* | Fold change (vs control) | |
|---|---|---|---|---|
| siWT1 RNA | sip63 RNA | |||
| Cell proliferation | MMP7 | Activator | 2.11 | 4.11 |
| NGFR | Activator | 0.47 | 0.36 | |
| IL8 | Activator | 0.46 | 2.22 | |
| IGFBP3 | Suppressor | 2.63 | 2.85 | |
| RARRES1 | Suppressor | 2.48 | 8.36 | |
| TIMP2 | Suppressor | 2.12 | 2.07 | |
| CDKN1B | Suppressor | 2.09 | 2.45 | |
| LDOC1 | Suppressor | 2.01 | 2.69 | |
| TOB2 | Suppressor | 0.48 | 0.36 | |
| SFN | Suppressor | 0.41 | 0.38 | |
| Cell cycle | TGM2 | Activator | 4.14 | 4.22 |
| Skp2 | Activator | 0.49 | 0.46 | |
| C13orf15 | Activator/Suppressor | 4.07 | 15.17 | |
| SMAD6 | Unspecified | 3.19 | 3.06 | |
| CITED2 | Unspecified | 2.30 | 3.18 | |
| DNA replication | MCM3 | Activator | 0.48 | 0.49 |
| MCM5 | Activator | 0.40 | 0.48 | |
| RFC3 | Activator | 0.37 | 0.44 | |
*Expected effect of the listed genes was based on previous studies.