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. 2015 May 6;46(1):50. doi: 10.1186/s13567-015-0178-z

Figure 5.

Figure 5

Most highly rated networks of genes triggered in PMEC after pathogen challenge. Network analysis was performed with top 50 up-regulated and top 50 down-regulated genes at 3 hpc and at 24 hpc with E. coli and S. aureus, respectively, and calculated by IPA. The down-regulated genes are in grey. (A) The gene interaction network of the early response (3 hpc) to E. coli was dominated by IL1A, NFKBIA, MAP3K8, JUN, FOS and EGR1. (B) CSF2, PTGS2, FOS and EGR1 are the key regulatory genes of the early response (3 hpc) to S. aureus. (C) The gene interaction network of the late response (24 hpc) to E. coli was dominated by TNFSF10, NFKBIA and FOS. (D) CSF2, FOS and PCNA are the key regulatory genes of the late response (24 hpc) to S. aureus.