Table 1.
Molecular and cellular functions affected in PMEC by pathogen challenge
| 3 h E. coli- challenged vs. unchallenged control cells | p -value | #Molecules |
|---|---|---|
| Gene Expression | 1.72E-14 - 1.71E-04 | 46 |
| Cellular Growth and Proliferation | 3.56E-14 - 3.13E-04 | 55 |
| Cellular Development | 1.46E-13 - 3.95E-04 | 52 |
| Cell Death and Survival | 1.29E-11 - 3.95E-04 | 50 |
| Cellular movement | 4.13E-11 - 3.95E-04 | 40 |
| 3 h S. aureus- challenged vs. unchallenged control cells | p -value | #Molecules |
| Small Molecule Biochemistry | 4.30E-08 - 4.53E-03 | 14 |
| Drug Metabolism | 2.15E-07 - 4.53E-03 | 8 |
| Lipid Metabolism | 2.15E-07 - 4.53E-03 | 11 |
| Vitamin and Mineral Metabolism | 2.15E-07 - 3.39E-03 | 4 |
| Energy Production | 8.97E-07 - 2.27E-03 | 4 |
| 24 h E. coli- challenged vs. unchallenged control cells | p -value | #Molecules |
| Cellular Growth and Proliferation | 1.46E-15 - 5.35E-03 | 255 |
| RNA Post-Transcriptional Modification | 3.21E-14 - 4.88E-03 | 53 |
| Cell Cycle | 1.46E-12 - 4.88E-03 | 115 |
| Cell Death and Survival | 7.44E-10 - 5.09E-03 | 226 |
| Cellular Development | 4.90E-08 - 5.35E-03 | 219 |
| 24 h S. aureus- challenged vs. unchallenged control cells | p -value | #Molecules |
| RNA Post-Transcriptional Modification | 9.24E-15 - 1.62E-02 | 42 |
| Cell Cycle | 8.61E-10 - 1.62E-02 | 95 |
| Cellular Growth and Proliferation | 8.88E-10 - 1.37E-02 | 202 |
| Cell Death and Survival | 4.29E-08 - 1.62E-02 | 187 |
| Gene Expression | 3.25E-07 - 6.69E-03 | 156 |
Top five categories of molecular and cellular functions affected in PMEC at 3 h and at 24 h post-challenge with E. coli and S. aureus, respectively, compared with unchallenged control cells with their respective p-value and number of molecules included in each class obtained from IPA software.