Table 4.
Down-regulated canonical pathways in PMEC at 3 hpc
| E. coli- challenged vs. unchallenged control cells | |
|---|---|
| Canonical pathway (Genes involved in pathway) | p -value |
| BMP signaling pathway(SOSTDC1,JUN,BMP4,BMP2) | 1.27E-04 |
| Regulation of IL-2 Expression in Activated and AnergicT Lymphocytes(FOS,JUN,NFKBIA,VAV3) | 1.55E-04 |
| TGF-b Signaling(FOS,JUN,BMP4,BMP2) | 1.79E-04 |
| T Cell Receptor Signaling(FOS,JUN,NFKBIA,VAV3) | 2.84E-04 |
| PKCq Signaling in T Lymphocytes(FOS,JUN,NFKBIA,VAV3,MAP3K8) | 4.80E-04 |
| S. aureus- challenged vs. unchallenged control cells | |
| Canonical pathway (Genes involved in pathway) | p -value |
| Differential Regulation of Cytokine Production inMacrophages and T Helper Cells by IL-17A and IL-17 F(CXCL1,CSF2) | 1.75E-04 |
| Role of Tissue Factor in Cancer(EGR1,CXCL1,JAK2,CSF2) | 2.35E-04 |
| Differential Regulation of Cytokine Production inIntestinal Epithelial Cells by IL-17A and IL-17 F (CXCL1,CSF2) | 2.88E-04 |
| IL-17A Signaling in Gastric Cells(FOS,CXCL1) | 3.42E-04 |
| MIF Regulation of Innate Immunity(FOS,PTGS2) | 9.24E-04 |
Top five categories of down-regulated canonical pathways in PMEC at 3 hpc with E. coli and S. aureus, respectively, compared with unchallenged control cells with their respective p-value and genes involved in each pathway obtained from IPA software.