Table 3.

Comparison of Aspergillus -specific lateral-flow device test and conventional bronchoalveolar lavage culture performance for diagnosing probable or proven versus no invasive pulmonary aspergillosis ^a

Probable or proven IPA versus no IPA	LFD	Conventional BAL culture
Sensitivity	80% (16/20)	50% (10/20)
Specificity	81% (88/108)	85% (88/103)
PPV	44% (16/36)	40% (10/25)
NPV	96% (88/92)	90% (88/98)
DOR (95% CI)	17.6 (5.3 to 58.3)	5.9 (2.1 to 16.5)

^aBAL, Bronchoalveolar lavage; CI, Confidence interval; DOR, Diagnostic odds ratio; IPA, Invasive pulmonary aspergillosis; LFD, Aspergillus-specific lateral-flow device test; NPV, Negative predictive value; PPV, Positive predictive value. According to European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria [34], probable IPA cases require mycological evidence by positive Aspergillus spp BAL culture, cytology, microscopy or positive galactomannan tests, in addition to host factors and clinical criteria.