Figure 5.

T-tubule damage is reversible. Top panel displays in situ images of T-tubules from the LV of wildtype (WT – left) and Gαq mice (center) treated with tamoxifen for 2 weeks, and Gαq mice treated with tamoxifen for 2 weeks following by tamoxifen withdrawal for 3 weeks (recovery – right). Bottom panel shows quantitative assessment of T-tubule organization by power spectrum analysis (TT_power). T-tubule integrity in the Gαq recovery group was almost restored to normal levels. **P < 0.01 vs. WT, ^††P < 0.01 vs Gαq mice treated with tamoxifen for 2 weeks. Data are adapted from Wu et al. (2014).