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. 2015 May 6;9:172. doi: 10.3389/fncel.2015.00172

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Copyright © 2015 Derghal, Djelloul, Airault, Pierre, Dallaporta, Troadec, Tillement, Tardivel, Bariohay, Trouslard and Mounien.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of leptin central administration on miRNA levels in the hypothalamus. (A) Daily food intake in saline-injected and leptin-treated mice at baseline (day 1 before injection) and with daily i.c.v injections of leptin (2.5 μg; days 2–5). (B) Effect of leptin treatment on body weight. (C) Hypothalamic POMC mRNA expression in i.c.v leptin-treated mice and saline-treated animals. (D) Hypothalamic mir-383, mir-384-3p, and mir-488 expression in i.c.v leptin-treated mice and saline-treated animals. Arrows indicate the injections. Values represent the mean ± SEM (n = 7). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. saline-treated animals.