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. Author manuscript; available in PMC: 2015 May 6.
Published in final edited form as: Dev Biol. 2014 Jan 10;387(1):109–120. doi: 10.1016/j.ydbio.2013.11.018

Fig. 2.

Fig. 2

Deletion of Sox17 in the developing lung mesenchyme causes dilated pulmonary vessels. (A–B) H&E staining of tissue sections from E18.5 mouse lungs shows enlarged pulmonary vessels in Sox17Δ/Δ embryos (B) compared to controls (A). (C–H) Immunostaining for Sox17 on sections from E18.5 control (C, E, and F) and Sox17Δ/Δ (D, G, and H) lungs. Dermo1-Cre mediated deletion of Sox17 results in the loss of Sox17 expression in the majority of arterial, venous, and microvascular endothelial cells in the developing lung. (E–H) Higher magnification images of arteries (F and H) and veins (E and G) shown in C and D. a, Artery; v, vein. Scale bars, 50 μm.