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. 2015 May 6;6:211. doi: 10.3389/fimmu.2015.00211

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Copyright © 2015 Fischer, Wolfram, Binder, Böhmig, Wahrmann, Eibl and Wolf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between reduced blood group anti-A/B IgM antibodies and defective IgM-antibody response to pneumococcal polysaccharides (upper panel) or reduced serum IgM levels (lower panel) in CVID patients. Serum IgM antibodies against 23-valent pneumococcal polysaccharides (PnP–IgM) were determined by ELISA, serum blood group anti-A/B IgM antibodies were assessed using isotype-specific surface plasmon resonance technology, serum IgM levels were measured by nephelometry. Results are depicted as reciprocal serum titer (for PnP–IgM), resonance units (RU, for anti-A/B IgM-antibodies), and mg/dl (for serum IgM). The Bravais–Pearson-correlation coefficient was calculated to determine a statistically significant correlation at a level ofP < 0.05.