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. 2015 Apr 23;16(1):124. doi: 10.1186/s12859-015-0567-3

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© Dalton et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A comparison of inactive states (in pink) and active states (in cyan) of Class A GPCRs (extracellular view): (A) and (B): adenosine A2A receptor, (C) and (D): rhodopsin, (E) and (F): β2-adrenergic receptor, investigate pathways of activation(G) and (H): muscarinic acetylcholine M2 receptor, (I) and (J): P2Y purinoceptor12. Binding-site volumes (in magenta) were calculated with POVME [52].