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Average interhelical distances extracted from 18 inactive and 7 active class A GPCR structures. Distances are calculated between Cα atoms of central and highly conserved residues in the 7TM core: G/I1.46, D2.50, I/V3.40, W4.50, P5.50, F6.44, S/C7.46 (Ballesteros-Weinstein numbering [60]). Standard error bars are shown. *denotes statistical significance between inactive and active states with Student’s t-test after Bonferroni correction for multiple testing.
