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. 2015 Apr 23;16(1):124. doi: 10.1186/s12859-015-0567-3

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© Dalton et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A comparison of antagonists (magenta) in inactive states (pink) and agonists (teal) in active states (cyan) of Class A GPCRs: (A, B) rhodopsin, (C, D) adenosine A2A, (E, F) β2-adrenergic, (G, H) muscarinic acetylcholine M2, (I, J) P2Y purinoceptor 12. Only side-chains on TM6 and TM7 that make covalent or H-bonds with antagonists/agonists are displayed. H-bonds shown as black lines, calculated with CHIMERA [68]. Agonists typically make more H-bonds with TM6/7 than respective antagonists.