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. 2015 Apr 21;11:20. doi: 10.1186/s12990-015-0021-6

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© Yamanaka et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Analysis of the response to pinch stimuli in the presence of AITC under hyperpolarization. (A) Continuous chart recording of membrane potential before and during the action of AITC (300 μM; top). Pinch stimuli applied to the ipsilateral hindlimb produced a barrage of EPSPs accompanied by action potentials under a current-clamp condition (bottom left). AITC (300 μM) hyperpolarized the membrane of a SG neuron and inhibited the action potentials (bottom right). (B) Analysis of evoked EPSPs and action potentials with noxious stimuli to the ipsilateral hindlimb. The area significantly decreased during AITC perfusion compared with control in the absence of AITC (n = 5). *P < 0.05.