Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
FXR regulation of hepatic glucose metabolism. FXR signaling phosphorylates and inhibits glycogen synthase kinase 3β (GSK3β), which is an inhibitor of glycogen synthase activity. This results in stimulating glycogenesis. The FXR/SHP pathway inhibits PEPCK and glucose 6-phosphatase (G6Pase) to inhibit gluconeogenesis. This results in increasing glucose tolerance and insulin sensitivity.
