Table 3.
ORs for having mineral levels outside target range
| Variable | Calcium | Phosphate | PTH | |||
|---|---|---|---|---|---|---|
| Low | High | Low | High | Low | High | |
| Age (yr)a | ||||||
| 0–2 | — | — | — | — | — | — |
| 3–5 | 0.47 (0.34 to 0.65)b | 0.68 (0.43 to 1.08) | — | — | 1.76 (0.67 to 4.63) | 1.11 (0.71 to 1.73) |
| 6–12 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| 13–17 | 0.43 (0.34 to 0.53)b | 1.35 (1.04 to 1.76)b | 0.28 (0.20 to 0.38)b | 10.08 (6.15 to 16.53)b | 2.46 (1.29 to 4.68)b | 0.98 (0.75 to 1.28) |
| Sex | ||||||
| Female | 0.76 (0.60 to 0.97)b | 1.25 (0.95 to 1.65) | 0.86 (0.66 to 1.12) | 0.60 (0.45 to 0.80)b | 0.73 (0.40 to 1.34) | 1.05 (0.81 to 1.37) |
| Male | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Time on transplantation (yr)c | ||||||
| <0.5 | 0.39 (0.26 to 0.61)b | 3.05 (1.64 to 5.69)b | 1.80 (1.06 to 3.06)b | 1.45 (0.84 to 2.48) | 0.31 (0.06 to 1.78) | 3.26 (1.93 to 5.51)b |
| 0.5 < 1 | 0.50 (0.34 to 0.75)b | 2.65 (1.64 to 4.29)b | 0.96 (0.50 to 1.82) | 1.38 (0.77 to 2.43) | 0.25 (0.05 to 1.35) | 1.88 (1.15 to 3.06)b |
| 1 < 2.5 | 0.65 (0.50 to 0.87)b | 1.17 (0.70 to 1.96) | 0.73 (0.47 to 1.14) | 1.33 (0.89 to 1.98) | 0.42 (0.15 to 1.15) | 1.61 (1.08 to 2.39)b |
| ≥2.5 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Preemptive transplantc | ||||||
| Yes | 1.54 (1.17 to 2.02)b | 0.43 (0.28 to 0.64)b | 0.88 (0.62 to 1.25) | 0.72 (0.50 to 1.04) | 1.37 (0.71 to 2.63) | 0.64 (0.48 to 0.86)b |
| No | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Time on dialysis before transplant (yr)c | ||||||
| <0.25 | 1.03 (0.51 to 2.05) | 1.92 (0.97 to 3.77) | 0.24 (0.06 to 0.92)b | 0.93 (0.50 to 1.71) | — | — |
| 0.25 < 1 | 0.80 (0.56 to 1.14) | 0.96 (0.65 to 1.41) | 1.08 (0.70 to 1.68) | 1.03 (0.72 to 1.49) | 1.06 (0.44 to 2.54) | 1.02 (0.68 to 1.50) |
| 1 < 2 | 0.87 (0.61 to 1.23) | 1.29 (0.88 to 1.88) | 1.10 (0.70 to 1.72) | 0.69 (0.45 to 1.05) | 0.94 (0.40 to 2.24) | 0.79 (0.55 to 1.13) |
| ≥2 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Steroidsd | ||||||
| Yes | 1.00 | 1.00 | 1.00 | 1.00 | — | — |
| No | 0.41 (0.20 to 0.83)b | 1.43 (0.83 to 2.46) | 0.60 (0.26 to 1.35) | 1.56 (0.86 to 2.81) | — | — |
| Calcineurin inhibitorsd | ||||||
| Cyclosporin A | 1.00 | 1.00 | 1.00 | 1.00 | — | — |
| Tacrolimus | 2.34 (1.54 to 3.55)b | 0.35 (0.22 to 0.56)b | 1.07 (0.73 to 1.57) | 1.09 (0.67 to 1.77) | — | — |
| None | 5.71 (2.85 to 11.42)b | 0.16 (0.05 to 0.54)b | 1.09 (0.33 to 3.66) | 1.53 (0.74 to 3.16) | ||
ORs are presented with 95% CIs. Dashes indicate that the number of patients with levels below or above target range in this category was too low to obtain an effect estimate. OR, odds ratio; 95% CI, 95% confidence interval; PTH, parathyroid hormone.
a
Adjusted for sex.
b
Significantly different from 1.
c
Adjusted for age, sex, and year of transplantation.
d
Adjusted for age, sex, time since transplantation, year of transplantation, and eGFR.