Comparison of tubulointerstitial lesions between patients with and without renal TMA. Tubulointerstitial lesions were scored semiquantitatively on the basis of the percentage of the affected compartment: interstitial infiltrates (− for 0%, + for 1%–20%, ++ for 21%–50%, and +++ for >50%), interstitial fibrosis (− for 0%, + for 1%–50%, and ++ for >50%), and tubular atrophy (− for 0%, + for 1%–50%, and ++ for >50%). TMA, thrombotic microangiopathy.