Table 4.
Associations of target weight misses and secondary outcomes during the 30-day baseline period
| Secondary Outcome | No. of treatments (%) with Outcome/No. of treatments without Outcome (n=131,333) | Logistic Adjusted ORa (95% CI) | Generalized Estimating Equation Adjusted ORb (95% CI) |
|---|---|---|---|
| IDH (nadir SBP<90 mmHg) | |||
| >2 kg above target in <30% tmts | 10,179 (9.1)/102,126 (90.9) | 1.00 (ref.) | 1.00 (ref.) |
| >2 kg above target in ≥30% tmts | 2,281 (12.0)/16,747 (88.0) | 1.43 (1.18 to 1.73) | 1.32 (1.19 to 1.47) |
| >2 kg below target in <30% tmts | 11,772 (9.6)/111,325 (90.4) | 1.00 (ref.) | 1.00 (ref.) |
| >2 kg below target in ≥30% tmts | 688 (8.4)/7548 (91.6) | 0.83 (0.61 to 1.14) | 0.96 (0.82 to 1.46) |
| Rapid UF rate (>13 ml/h per kg) | |||
| >2 kg above target in <30% tmts | 29,129 (25.9)/83,176 (74.1) | 1.00 (ref.) | 1.00 (ref.) |
| >2 kg above target in ≥30% tmts | 5902 (31.0)/13,126 (69.0) | 1.29 (1.08 to 1.54) | 1.17 (1.11 to 1.25) |
| >2 kg below target in <30% tmts | 33,224 (27.0)/89,873 (73.0) | 1.00 (ref.) | 1.00 (ref.) |
| >2 kg below target in ≥30% tmts | 1807 (21.9)/6429 (78.1) | 1.58 (1.24 to 2.02) | 1.14 (1.05 to 1.25) |
| Large IDWG (>3.5% body weight) | |||
| >2 kg above target in <30% tmts | 52,775 (47.0)/59,530 (53.0) | 1.00 (ref.) | 1.00 (ref.) |
| >2 kg above target in ≥30% tmts | 10,903 (57.3)/8125 (42.7) | 1.68 (1.32 to 2.13) | 1.09 (1.04 to 1.15) |
| >2 kg below target in <30% tmts | 60,675 (49.3)/62,422 (50.7) | 1.00 (ref.) | 1.00 (ref.) |
| >2 kg below target in ≥30% tmts | 3003 (36.5)/5233 (63.5) | 0.86 (0.64 to 1.15) | 0.92 (0.85 to 0.99) |
OR, odds ratio; 95% CI, 95% confidence interval; IDH, intradialytic hypotension; SBP, systolic BP; tmts, dialysis treatment; ref., reference population; UF, ultrafiltration; IDWG, interdialytic weight gain.
Separate logistic multivariable models considered the outcome of interest as binary (present in ≥30% of baseline treatments versus not) and contained exposure terms for both above and below weight and were adjusted for age, sex, race (black or nonblack), coronary artery disease, heart failure, diabetes, vascular access type (fistula, graft, or catheter), albumin (≤2.9, 3–3.9, and ≥4.0 g/dl), phosphorus (milligrams per deciliter), hemoglobin (grams per deciliter), equilibrated Kt/V, dialytic vintage (≤1.0, 1.1–1.9, 2.0–3.9, and ≥4.0 years), prescribed treatment time (minutes), IDWG (kilograms), postdialysis weight (≤62.7, 62.8–74.0, 74.1–88.9, and ≥89.0 kg), predialysis systolic blood pressure (≤130, 131–150, and ≥151 mmHg), and missed dialysis treatments (0, 1, 2, and ≥3). The model for IDWG did not include adjustment for postweight or IDWG.
Separate generalized estimating equations considered the outcome of interest on a treatment-to-treatment basis in the baseline period and within-subject correlation was accounted for via an exchangeable covariance. Model exposures and covariates were analogous to logistic models.