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. 2015 Apr 15;14:85. doi: 10.1186/s12943-015-0347-8

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© Apostoli et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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In vivo effects of MG-specific PPARγ loss on survival and total tumour outcomes. Overall survival outcomes for (A) PPARγ-WT and (B) PPARγ-MG KO mice are shown. Solid lines, DMBA Only treatment; broken lines, DMBA + ROSI treatment. Overall survival for (C) DMBA Only- and (D) DMBA + ROSI-treated mice are shown. Solid lines, PPARγ-WTs; broken lines, PPARγ-MG KOs. (E) Tumour incidences are shown for each strain across each treatment group for total, mammary, ovarian, liver, lung, skin and thymic tumours. *, p < 0.05; **, p < 0.01.