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. 2014 Jul 18;13:113. doi: 10.1186/s12933-014-0113-z

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Copyright © 2014 Yu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Arg-II gene deficiency prevents HFD-induced impairment of endothelium-dependent relaxation. (A) Endothelium-dependent relaxations in response to acetylcholine (ACh) were significantly impaired by HFD feeding in WT mice () and preserved in Arg-II^-/- mice (). Arg-II deficiency had no significant effects in mice fed NC. (B) Arg-II deficiency does not affect endothelium-independent relaxations in response to the NO donor sodium nitroprusside (SNP) in animals fed HFD. n = 6, **p < 0.01 between WT HFD and Arg-II^-/- HFD groups.