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SCID mice have enhanced renal cyclooxygenase (COX)-2 expression and urinary excretion of vasodilatory prostaglandins in ANG II-dependent hypertension. A: relative expression in kidney of COX-1 and COX-2 after 28 days of ANG II infusion. *P = 0.05 vs. C3H wild type (WT). B and C: urinary excretion of metabolites for prostaglandin E2 (B) and prostacyclin (prostaglandin I2) (C) measured by ELISA following 25 days of ANG II infusion. *P = 0.05 vs. C3H WT.
