Figure 2.

Uterine artery ligation in rats confers heritable growth restriction and adult obesity. A) F2 pups at birth from F1 IUGR^pat/IUGR^mat lineage and F1 Sham^pat/Sham^mat lineage show substantial birth weight differences. B) Differences in mean birth weight of the F2 generation from the F1 lineage fed either a control or ENS diet. Significant differences from Sham^pat/Sham^mat control diet are indicated. C) F2 males at p160 from the IUGR^pat/IUGR^mat lineage fed either a control or ENS diet. Mean p160 weights for F2 male (D) and female (E) rats, bred from the F1 lineage that were fed either a control or ENS diet. Significant differences from Sham^pat/Sham^mat control diet are indicated. (^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001, 1-way ANOVA with Bonferroni’s post hoc test).