Figure 2.

STAT3C-transduced CD4⁺ T cells are hyporesponsive. A) Proliferation of STAT3⁺, STAT3C⁺, or control-transduced T cells in response to anti-CD3/anti-CD28 coated microbeads at the indicated bead to cell ratio. B, C) Proliferation of control vector–transduced, STAT3C⁺, or FOXP3⁺ T cells in response to anti-CD3/anti-CD28 coated microbeads (B) or aAPC expressing a membrane-bound OKT3scFv plus CD58 at the indicated stimulator to T cell ratios (C). Mean values ± sd from triplicate cultures from 1 representative experiment are depicted. D) Percent values normalized for control-transduced T cells from 6 experiments. n.s., not significant; **P < 0.01; ***P < 0.001.