TABLE 1.

Top canonical pathways and associated molecules modulated between CXCR3⁺ and CXCR3⁻ innate CD8⁺ T cells

Ingenuity canonical pathway	Molecules
eIF2 signaling	RPS2, RPS19, RPL30, RPS21, eIF4A2, RPL37A, RPLP0, RPS12, RPS7, RPL14, RPL8, RPL35, RPS16, RPS9, RPL5, RPS3, RPL13, RPL13A, RPSA, RPL38
Regulation of eIF4 and p70S6K signaling	ITGB1, RPS7, RPS16, RPS2, RPS9, RPS19, eIF4A2, RPS21, RPS3, RPS12, RPSA
mTOR signaling	RPS7, RPS16, RPS2, RPS9, RPS19, eIF4A2, RPS21, RPS3, RPS12, RPSA
T helper cell differentiation	IFNGR2, TBX21, IL18R1
Mitochondrial dysfunction	COX7B, NDUFA3, PSENEN, Atp5e
Granulocyte adhesion and diapedesis	ITGB1, XCL1, CCL5, IL18RAP
Oxidative phosphorylation	COX7B, NDUFA3, Atp5e
Hepatic fibrosis/hepatic stellate cell activation	IFNGR2, CCL5, FASLG, IL18RAP
NK cell signaling	Klra4, HCST, KLRC1
Eumelanin biosynthesis	MIF
Chondroitin and dermatan biosynthesis	CHSY1
Thioredoxin pathway	TXN
Cell cycle: G1/S checkpoint regulation	PA2G4, RPL5
IL-15 signaling	FASLG, IL2RB