TABLE III.

URINARY LEVELS OF ESTROGEN COMPOUNDS IN HEALTHY WOMEN, HIGH-RISK WOMEN AND WOMEN WITH BREAST CANCER

No.	Compound	Control (n = 46)		High Risk (n = 12)			Breast Cancer (n = 18)
		Median	Min–Max	Median	Min–Max	p-value3	Median	Min–Max	p-value4
1	Androstenedione	9.9	2.1–108	4.2	1.3–11.5	0.0033	5.5	0.4–95.1	0.047
2	Testosterone	2.2	0.2–16.5	0.8	0.2–2.8	0.0085	1.1	0.5–3.7	0.050
3	E1-Sulfate	5.0	0.1–382	2.4	0.1–10.6	0.087	1.1	0.1–121	0.032
4	E2	31.7	9.1–3865	11.4	4.7–80.0	0.007	28.1	3.6–151	0.943
5	E1
6	2-OHE2	10.4	1.7–564	7.3	1.6–26.5	0.035	5.6	0.0–38.8	0.006
7	2-OHE1
8	4-OHE2	12.4	2.4–157	8.1	2.9–43.3	0.138	5.2	0.0–28.0	0.008
9	4-OHE1
10	16α-OHE2	168	10.3–638	33.7	0.0–279	0.001	10.9	0.0–86.3	<0.001
11	16α-OHE1
12	2-OCH3E2	49.7	4.7–568	31.1	6.5–452	0.275	26.8	2.2–171	0.044
13	2-OCH3E1
14	4-OCH3E2	73.1	12.6–3979	5.9	1.6–37.1	<0.001	21.5	4.5–53.2	<0.001
15	4-OCH3E1
16	2-OH-3-OCH3E2
17	2-OH-3-OCH3E1
18	2-OHE2-1-SG	11.21	0.8–79.81	4.61	1.2–18.71	0.0051	3.11	1.1–16.91	0.0011
19	2-OHE2-4-SG
20	2-OHE1-1-SG
21	2-OHE1-4-SG
22	2-OHE2-1+4-Cys
23	2-OHE1-1-Cys
24	2-OHE1-4-Cys
25	2-OHE2-1-NAcCys
26	2-OHE2-4-NAcCys
27	2-OHE1-1-NAcCys
28	2-OHE1-4-NAcCys
29	4-OHE2-2-SG	2.72	0.7–24.62	1.42	0.6–6.82	0.0322	1.32	0.4–8.92	0.0272
30	4-OHE1-2-SG
31	4-OHE2-2-Cys
32	4-OHE1-2-Cys
33	4-OHE2-2-NAcCys
34	4-OHE1-2-NAcCys
35	4-OHE2-1-N7Gua	0.7	0.0–4.8	1.2	0.2–2106	0.238	1.6	0.4–11.8	0.007
36	4-OHE1-1-N7Gua
37	4-OHE2-1-N3Ade	0.7	0.0–18.8	1.8	0.5–138	0.007	1.2	0.1–288	0.085
38	4-OHE1-1-N3Ade
39	2-OHE2-6-N3Ade	0.1	0.0–6.5	0.1	0.0–0.7	0.999	0.1	0.0–5.4	0.960
40	2-OHE1-6-N3Ade

¹All 2-OHE₁(E₂) conjugates.

²All 4-OHE₁(E₂) conjugates.

³Bonferroni-adjusted p-value for comparing control versus high risk using Mann–Whitney test.

⁴Bonferroni-adjusted p-value for comparing control versus breast cancer by using Mann–Whitney test.

⁵Significant p-values are shown in bold.