Table 1.

Chemokines in CRS

Chemokines	Potential role in CRSwNP	Finding	Source	Technique	Patient population	References
CCL2 (MCP-1)	Monocyte, T cell and DC recruitment	Not different between NP and control or CRSsNP	Tissue	Multiplex bead array	USA	C. J. Ocampo, unpublished observations
CCL5 (RANTES)	Eosinophil recruitment	Not different between NP and control	Tissue	Semi-quantitative PCR	Germany	Barrels et al. [59]
		Not different between NP and control	Tissue	ELISA	Germany	Bachert et al. [106]
		Decreased in NP compared to control and CRSsNP	Tissue	Multiplex bead array	USA	C. J.Ocampo, unpublished observations
CCL7 (MCP-3)	Monocyte recruitment	Not detectible in NP or control	Tissue	Semi-quantitative PCR	Germany	Barrels et al. [59]
CCL11 (Eotaxin-1)	Eosinophil recruitment	Not different between NP and control	Tissue	Semi-quantitative PCR	Germany	Barrels et al. [59]
		Elevated in NP compared to control	Tissue	ELISA	Belgium	Bachert et al. [60]
		Elevated in NP compared to control	Tissue	ELISA	Germany	Olze et al. [107]
		Elevated in NP compared to control and CRSsNP	Tissue	ELISA	Belgium	Van Zele et al. [87]
		Elevated in NP compared to control	Tissue	ELISA	Belgium*	Zhang et al. [90]
		Not different between NP and control	Tissue	ELISA	China*	Zhang et al. [90]
		Elevated in CRSwNP compared to control and CRSsNP	Nasal secretion	Multiplex bead array	USA	Cho et al. [108]
		Elevated in NP compared to control and CRSsNP	Tissue	Multiplex bead array	USA	C. J.Ocampo, unpublished observations
CCL13 (MCP-4)	Eosinophil and basophil recruitment	Elevated in NP compared to control and CRSsNP	Tissue	Multiplex bead array	USA	C. J.Ocampo, unpublished observations
CCL17 (TARC)	T cell recruitment	Elevated in NP compared to control and CRSsNP	Tissue	Multiplex bead array	USA	C. J.Ocampo, unpublished observations
CCL18 (PARC)	Lymphocyte and DC recruitment	Elevated in NP compared to control and CRSsNP	Tissue	PCR and ELISA	USA	Peterson et al. [64]
CCL23 (MIP-3)	Monocyte and macrophage recruitment	Elevated in NP compared to control and CRSsNP	Tissue	PCR	USA	Poposki, 2011 [109]
CCL24 (Eotaxin-2)	Eosinophil recruitment	Elevated in NP compared to control	Tissue	ELISA	Germany	Olze et al. [107]
		Elevated in NP compared to control and CRSsNP	Tissue	Multiplex bead array	USA	C. J.Ocampo, unpublished observations
CCL26 (Eotaxin-3)	Eosinophil recruitment	Elevated in NP compared to control	Tissue	ELISA	Germany	Olze et al. [107]
		Elevated in NP compared to control and CRSsNP	Tissue	Multiplex bead array	USA	C. J.Ocampo, unpublished observations
CXCL9 (MIG)	T cell recruitment	Elevated in CRSwNP compared to control and CRSsNP	Nasal secretion	Multiplex bead array	USA	Cho et al. [108]
CXCL1 (GRO-a)	T cell recruitment	Not different between NP and control	Tissue	ELISA	Germany	Bachert et al. [106]
CXCL12 (SDF-1a)	B cell recruitment	Elevated in NP compared to control and CRSsNP	Tissue	PCR and ELISA	USA	Patadia et al. [65]
CXCL13 (BLC)	B cell recruitment	Elevated in NP compared to control and CRSsNP	Tissue	PCR and ELISA	USA	Patadia et al. [65]
		Elevated in NP compared to control and CRSsNP	Tissue	Multiplex bead array	USA	C. J.Ocampo, unpublished observations

^*This work investigated patients from Belgium and China; for clarity, we have separated the results from these two distinct populations.