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. 2015 May 6;10(5):e0126653. doi: 10.1371/journal.pone.0126653

Fig 6. Let-7b chemosensitization of KRAS mutant cells is associated with the suppression of TUBB3 and RRM2.

Fig 6

A, the effect of let-7b mimic, paclitaxel or gemcitabine on TUBB3 protein in A549, NIH-H1975, Panc-1 and BxPC-3 cells was analyzed by Western blotting. B, the effect of let-7b mimic, paclitaxel or gemcitabine on TUBB3 mRNA in A549, NIH-H1975, Panc-1 and BxPC-3 cells was analyzed by qRT-PCR. C, the effect of let-7b mimic, paclitaxel or gemcitabine on RRM2 protein in A549, NIH-H1975, Panc-1 and BxPC-3 cells was analyzed by Western blotting. D, the effect of let-7b mimic, paclitaxel and gemcitabine on RRM2 mRNA in A549, NIH-H1975, Panc-1 and BxPC-3 cells was analyzed by qRT-PCR. Each experiment was carried out at least 3 times. Data represent the mean ± SEM. *, p < 0.05; **, p < 0.01.