Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 10;16:4. doi: 10.1186/s12881-015-0148-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Mtatiro et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Association of common genetic variation with HbF levels across the HBS1L-MYB intergenic region on chromosome 6q23.3. Shown are LOP (−log₁₀ [P-value]) scores for 1,022 patients, tested for association of ln[%HbF] with 109 common variants from a combination of Illumina Human Omnichip 2.5 data and PCR-based genotyping. A: Genetic association is present over the entire interval, but reaches genome-wide significance only at HMIP-2, whereas the other two LD blocks detected in Europeans (HMIP-1 and HMIP-3,[8]) display only low-level association in our dataset. B: HbF association at HMIP-2. The six SNPs showing strong association are indicated. In addition to un-conditioned analysis (black dots), the presence two partially independent association signals (sub-loci HMIP-2A and HMIP-32B) is shown by conditioning analysis on rs66650371 (tagging HMIP-2A, black diamonds) and rs9494145 (tagging HMIP-2B, open diamonds, see also Table 1).