Table 2.
Relative effects of HMIP-2 haplotypes on the ln[HbF%] trait
| Compared haplotypes | Difference | lower | upper | p adjusted |
|---|---|---|---|---|
| a-B1 vs. a-b | 0.029 | −0.35 | 0.40 | 1.00 |
| a-B 2 vs. a-b | 0.431 | 0.08 | 0.78 | 7 x 10 −3 |
| a-B 3 vs. a-b | 0.332 | 0.01 | 0.66 | 0.04 |
| A-b vs. a-b | 0.636 | 0.10 | 1.18 | 0.01 |
| A-B vs. a-b | 0.638 | −0.10 | 1.38 | 0.13 |
| a-B1 vs. a-B2 | −0.401 | −0.10 | 0.90 | 0.20 |
| a-B1 vs. a-B3 | −0.303 | −0.79 | 0.18 | 0.47 |
| a-B2 vs. a-B3 | 0.098 | −0.37 | 0.56 | 0.99 |
| a-B1 vs. A-b | −0.607 | −1.25 | 0.04 | 0.08 |
| a-B2 vs. A-b | −0.205 | −0.84 | 0.43 | 0.94 |
| a-B3 vs. A-b | −0.304 | −0.92 | 0.32 | 0.73 |
| A-B vs. A-b | 0.002 | −0.91 | 0.91 | 1.00 |
| a-B1 vs. A-B | −0.609 | −1.43 | 0.21 | 0.28 |
| a-B2 vs. A-B | −0.208 | −1.02 | 0.60 | 0.98 |
| a-B3 vs. A-B | −0.306 | −1.10 | 0.49 | 0.88 |
“Difference” represents the difference in effect size between the two haplotypes on log-transformed HbF levels; negative difference values indicates that the effect size of the second haplotype is bigger than that of the first. ‘lower’ and ‘upper’ represent boundaries for family-wise 95% confidence intervals. ‘p adjusted’ is the P-value adjusted for age, sex as well as multiple testing.
Three haplotypes (shown in bold) have significant HbF-boosting effects at the 0.05 level.