TABLE III.

Frequency of A Allele of SNP rs1447295 in Various Populations

Study	No. of cases	No. of controls	Frequency in cases	Frequency in controls	Odd ratios	95% CI	P-value
African ancestry
Bunker et al. 2,3 (Tobago men)	354	438	0.33	0.37	0.83	0.62–1.1	0.19
Robbins et al. 14 (African Americans)	490	567	0.34	0.31	1.4	0.7–1.3	0.131
Gudmundsson et al. 12 (AA, Baltimore)	373	372	0.315	0.313	1.01	0.81–1.25	0.96
Amundadottir et al. 9 (AA, Michig Gleason 7–10	112	352	0.352	0.313	1.19		0.28
Amundadottir et al. 9 (AA, Michig Gleason 2–6	121	352	0.341	0.313	1.14		0.43
Freedman et al. 10 (African Americans)	989	804			1.05	0.95–1.16	0.15
Cheng et al. 15 (African Americans)	91	89	0.315	0.320	0.87	0.55–1.40 (adjusted)	0.574 (adjusted)
Salinas et al. 16 (African Americans)	144	79			1.19	0.66–2.14	0.57
European ancestry
Amundadottir et al. 9 (Iceland) Gleason 7–10	289	997	0.179	0.106	1.84		7.3 × 10−6
Amundadottir et al. 9 (Iceland) Gleason 2–6	548	997	0.170	0.106	1.73		6.7 × 10−7
Amundadottir et al. 9 (Sweden) Gleason 7–10	625	779	0.167	0.133	1.29		2.0 × 10−2
Amundadottir et al. 9 (Sweden) Gleason 2–6	678	779	0.158	0.138	1.25		3.4 × 10−2
Amundadottir et al. 9 (European Americans, Chicago) Gleason 7–10	149	247	0.151	0.081	2.03		2.7 × 10−3
Amundadottir et al. 9 (European Americans, Chicago) Gleason 2–6	306	247	0.116	0.081	1.50		5.1 × 10−2
Gudmundsson et al. 12 Iceland	1,453	3,064	0.165	0.104	1.71	1.49–1.95	1.6 × 10−14
Gudmundsson et al. 12 Spain	385	892	0.103	0.074	1.44	1.07–1.94	0.017
Gudmundsson et al. 12 The Netherlands	367	1,302	0.144	0.108	1.39	1.09–1.78	9.0 × 10−3
Gudmundsson et al. (Eur Am, Chicago)	458	251	0.124	0.083	1.56	1.08–2.27	0.019
All Europeans				0.088	1.44	1.21–1.70	2.5 × 10−5

	No. of cases	No. of controls	Frequency in cases	Frequency in controls	OR (CA)	OR (AA)	P-value
Yeager et al. 13 PLCO	1,172	1,157	0.14	0.10	1.42 (1.16–1.73)	2.78 (1.32–5.86)	9.75 × 10−5
Yeager et al. 13 ACS	1,150	1,142	0.12	0.08	1.53 (1.23–1.90)	2.82 (1.30–6.14)	2.26 × 10−5
Yeager et al. 13 ATBC	894	896	0.21	0.17	1.24 (1.01–1.52)	1.64 (0.98–2.72)	2.88 × 10−2
Yeager et al. 13 FPCC	455	459	0.12	0.07	1.71 (1.20–2.43)	3.11 (0.62–15.71)	4.35 × 10−3
Yeager et al. 13 HPFS	625	636	0.13	0.09	1.56 (1.18–2.06)	2.51 (0.77–8.20)	2.74 × 10−3
Yeager et al. 13 ALL	4,296	4,299	0.11	0.11	1.43 (1.29–1.59)	2.23 (1.58–3.14)	1.53 × 10−14
Freedman et al. 10 (European Americans)	455	447	0.131	0.10	1.35	1.01–1.80	0.022 (one tailed)
Freedman et al. 10 (Latino Americans)	640	567	0.135	0.095	1.48	1.14–1.91	0.0014 (one tailed)
Freedman et al. 10 (Japanese Americans)	449	465	0.238	0.172	1.48	1.18–1.86	0.00034 (one tailed)
Freedman et al. 10 (Native Hawaiians)	70	68	0.370	0.162	3.02	1.66–5.50	0.00015 (one tailed)
Cheng et al. 15 (European Americans)	417	417	0.121	0.092	1.46 (adjusted)	1.06–2.02 (adjusted)	0.020 (adjusted)
Salinas et al. 16 (Caucasians)	1,252	1,263	0.14	0.10	1.36 (1.12–1.65) (GT)	2.08 (1.07–3.95) (TT)	0.0012