Fig 8. Transcriptional regulation of the CCN/ECCN extension network of 118 genes by REV-ERB and ROR.

Regulatory interactions of REV-ERB α/β with NCRG genes (green lines) were derived from the locations of physical binding of these proteins in two ChIP-seq experiments [16, 17]. The ROR α/ γ interactions (purple lines) were adopted from the report of a third ChIP-seq experiment [22]. Genes with an observed phenotype in the genome-wide RNAi screen [28, 29] are shown with a coloured box, red indicating long period, blue a high amplitude, and green a short period.