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. 2015 Apr 9;17(1):97. doi: 10.1186/s13075-015-0611-8

Table 3.

Number of adverse events per treatment group a

MTX-TSU COBRA Slim
n = 47 n = 43
AEs related to therapy 32 30
Type of related AEs 23 23
Discomfort
Toxicity 7 4
Infection 1 0
Others 1 3
Surgery 0 0
Severity of related AEs 29 28
Mild
Moderate 3 2
Severe 0 0
Serious AEs 0 0

aAE, Adverse event; COBRA Slim, COmbinatie therapie bij Reumatoïde Artritis; MTX-TSU, Methotrexate with tight step-up, 15 mg of MTX weekly, no oral steroids allowed. Protocol determines the severity rating of the adverse event: mild (does not interfere with daily living), moderate (somewhat interferes with daily living or medications needed to relieve event) or severe (incapacitating).