Table 3.
MTX-TSU | COBRA Slim | ||
---|---|---|---|
n = 47 | n = 43 | ||
AEs related to therapy | 32 | 30 | |
Type of related AEs | 23 | 23 | |
Discomfort | |||
Toxicity | 7 | 4 | |
Infection | 1 | 0 | |
Others | 1 | 3 | |
Surgery | 0 | 0 | |
Severity of related AEs | 29 | 28 | |
Mild | |||
Moderate | 3 | 2 | |
Severe | 0 | 0 | |
Serious AEs | 0 | 0 |
aAE, Adverse event; COBRA Slim, COmbinatie therapie bij Reumatoïde Artritis; MTX-TSU, Methotrexate with tight step-up, 15 mg of MTX weekly, no oral steroids allowed. Protocol determines the severity rating of the adverse event: mild (does not interfere with daily living), moderate (somewhat interferes with daily living or medications needed to relieve event) or severe (incapacitating).