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. 2015 Apr 30;12:39. doi: 10.1186/s12977-015-0167-3

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© Serrao et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Flexibility profiles for PFV and HIV-1 integration sites in nucleosome-free versus chromatinized tDNA. (A and B) YR and RY frequency charts, respectively, for PFV integration sites into deproteinized genomic DNA (PFV in vitro) and from virus infection. Vertical dotted black line represents central dinucleotide step(s), and horizontal dotted grey line represents the MRC frequency of YR/RY utilization. (C and D)) Bar graphs illustrating the percent YR and RY enrichment, respectively, at the central dinucleotide step relative to MRC values. (E and F) YR and RY frequency charts, respectively, for HIV-1 integration sites into naked plasmid DNA (HIV-1 in vitro) and from virus infection. (G and H) Bar graphs illustrating the percent YR and RY enrichment, respectively, at the central dinucleotide steps compared to MRC.