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. 2015 Apr 16;11(4):799. doi: 10.15252/msb.20145399

Figure 3. SH2B3‐related genetic and protein–protein interaction subnetworks.

Figure 3

  1. rs3184504, a missense SNP, is located in the third exon of SH2B3.
  2. SH2B3 genetic subnetwork. rs3184504 is associated with 19 genes in a cis or trans manner based on analysis of eQTLs.
  3. SH2B3 protein–protein interaction (PPI) subnetwork. SH2B3 is depicted as a rectangular node. Green nodes indicate differentially expressed BP genes at Bonferroni‐corrected P < 0.05 in the Framingham Heart Study (FHS) data (BP Top Sig); turquoise nodes indicate genes in the BP causal coEMs; yellow nodes indicate genes that are in both the BP Top Sig set and the BP causal coEMs. The nodes marked with a red border indicate differentially expressed genes between wild‐type (WT) and Sh2b3 −/− mice.