Table 3.
SNP set enrichment analysis of BP coexpression modules and BP signature gene set
| Module | SBP GWAS | DBP GWAS | ||||||
|---|---|---|---|---|---|---|---|---|
| KS P | Permutation‐based KS P a | Fisher P | Permutation‐based Fisher P a | KS P | Permutation‐based KS P | Fisher P | Permutation‐based Fisher P a | |
| BP signature | 0.98 | 0.96 | 1 | 1 | 0.20 | 0.23 | 1 | 1 |
| Turquoise | 2.8e‐45 | < 0.001 | 7.8e‐115 | < 0.001 | 1.8e‐28 | < 0.001 | 3.0e‐39 | < 0.001 |
| Blue | 1.4e‐44 | < 0.001 | 7.0e‐54 | < 0.001 | 1.3e‐8 | < 0.001 | 3.4e‐15 | < 0.001 |
| Red | 8.0e‐5 | < 0.001 | 1.7e‐17 | < 0.001 | 2.2e‐15 | < 0.001 | 6.7e‐19 | < 0.001 |
| Purple | 0.65 | 0.71 | 0.58 | 0.61 | 1 | 1 | 1 | 1 |
| Lightyellow | 1.6e‐3 | 0.004 | 1 | 1 | 0.12 | 0.16 | 1 | 1 |
| Chocolate | 2.3e‐14 | < 0.001 | 5.0e‐5 | < 0.001 | 0.07 | 0.06 | 1 | 1 |
a
Permutation‐based P is empirically derived based on 1,000 permutations (see Materials and Methods). < 0.001 indicates none of the 1,000 random gene sets of matching size had P‐values lower than the observed test P‐values.