Table 5.
Top key drivers (KDs)
| KD | Cellular network | TWAS | GWAS | |||
|---|---|---|---|---|---|---|
| KD P‐value, corrected for subnetwork size | Tissue / network | P‐valuea for BP TWAS | eSNP ID | P‐valueb in ICBP GWAS | BP coEM | |
| Top BP GWAS KDs | ||||||
| SH2B3 | 4.4e‐4 | HPRD | rs653178 | 1.6e‐14 | Turquoise | |
| ATXN2 c | 2.2e‐5 | HPRD | rs3742004 | 2.2e‐8 | Turquoise | |
| NMT1 | 1.6e‐5 | HPRD | rs12946454 | 8.9e‐8 | Turquoise | |
| NSF | 5.0e‐9 | HPRD | rs17608766 | 7.3e‐7 | Turquoise | |
| HSPA1B | 2.1e‐9 | HPRD | rs805303 | 1.3e‐6 | Blue | |
| BAT2 | 5.4e‐7 | HPRD | rs805303d | 1.3e‐6 | Turquoise | |
| MAPKAPK5 c | 2.8e‐8 | HPRD | rs4767293 | 1.5e‐6 | Turquoise | |
| Top BP TWAS KDs | ||||||
| GZMB c | 2.0e‐23 | Blood | 4.8e‐22 | Chocolate | ||
| PRF1 | 2.0e‐26 | Blood | 2.5e‐9 | Chocolate | ||
| GPR56 | 1.2e‐26 | Blood | 3.5e‐9 | Chocolate | ||
| RAB11FIP1 | 1.3e‐3 | Blood | 4.0e‐8 | Turquoise | ||
| HIPK1 c | 3.1e‐8 | HPRD | 9.1e‐8 | Turquoise | ||
| GZMH c | 5.4e‐24 | Blood | 3.3e‐7 | Chocolate | ||
| VIM | 6.0e‐3 | HPRD | 4.2e‐7 | Turquoise | ||
| BCL2L11 c | 1.8e‐10 | HPRD | 1.7e‐6 | Blue | ||
| BHLHE40 c | 3.8e‐7 | HPRD | 2.2e‐6 | Turquoise | ||
| KLRD1 | 1.2e‐30 | Blood | 2.5e‐6 | Chocolate | ||
| TGFBR3 | 1.1e‐26 | Blood | 2.5e‐6 | Chocolate | ||
| Top multi‐tissue/ network KDs | ||||||
| DCLRE1C c | 1.1e‐16 | HPRD, Blood | Blue | |||
| ERCC6 | 8.8e‐14 | HPRD, Blood | Turquoise | |||
a
P‐values passing transcriptome‐wide significance at Bonferroni‐corrected P < 0.05 (corrected for 17,318 measured genes).
b
Minimum P‐values for SBP, DBP, and HTN associations.
c
Indicating the KD could be replicated in BioGrid PPI database (Chatr‐Aryamontri et al, 2013).
d
trans‐eSNP; other eSNPs are cis‐eSNPs.
PPI, protein–protein interaction; HPRD, Human Protein Reference Database (Keshava Prasad et al, 2009).