Table 1.
Therapeutic effects of traditional treatments and stem cells-based therapies for AD
| Therapeutic effects | Chemical treatments | Stem-cells based therapies |
|---|---|---|
| Neuron replacement | None | ESCs |
| NSCs | ||
| MSCs | ||
| iPSCs | ||
| iNPCs | ||
| Aβ’s reduction | Solanezumab (clinical trials failed) | NSCs |
| Bapineuzumab (clinical trials failed) | MSCs | |
| Semagacestat (clinical trials failed) | ||
| Neuron protective/neurotrophic action | Memantine | MSCs |
| Donepezl | ||
| Tacrine | ||
| Galanthamine | ||
| Rivastigmine | ||
| Huperzine A | ||
| N-acetyl-L-cysteine | ||
| Immune modulating | Nonsteroidalantiinflammatory drugs | MSCs |