Fig 6. Sensitivity of T. brucei towards trypanocidal cations.

A) Sensitivity to pentamidine of bloodstream forms cultured in the absence (black squares) or presence (red circles) of tetracycline to down-regulate TbMCP14 expression. Data points are from one of two experiments and represent mean values ± SEM of triplicate determinations. B) Sensitivity to pentamidine of procyclic forms cultured in the absence (black squares) or presence (red circles) of tetracycline to induce TbMCP14 over-expression. Data points are from one of three experiments and represent mean values ± SEM of triplicate determinations. C) Compilation of EC₅₀ values for different trypanocidal cations for procyclic forms cultured in the absence (-tet) or presence (+tet) of tetracycline to over-express TbMCP14. The numbers represent mean values ± standard deviations from three independent experiments.