Table 5. Rank Order of Genotypes in Each β-Lactam Antibiotic (Derived From Table 4).
| Antibiotic | 0000 | 1000 | 0100 | 0010 | 0001 | 1100 | 1010 | 1001 | 0110 | 0101 | 0011 | 1110 | 1101 | 1011 | 0111 | 1111 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP | 11 | 12 | 9 | 10 | 7 | 5 | 15 | 6 | 8 | 4 | 2 | 13 | 3 | 14 | 16 | 1 |
| AM | 8 | 11 | 14 | 3 | 7 | 12 | 6 | 4 | 15 | 13 | 10 | 9 | 1 | 5 | 16 | 2 |
| CEC | 4 | 12 | 3 | 7 | 9 | 8 | 5 | 14 | 6 | 10 | 1 | 2 | 15 | 16 | 13 | 11 |
| CTX | 11 | 10 | 7 | 6 | 16 | 8 | 5 | 12 | 3 | 13 | 2 | 14 | 15 | 9 | 4 | 1 |
| ZOX | 14 | 11 | 8 | 5 | 15 | 10 | 7 | 9 | 4 | 6 | 2 | 3 | 12 | 16 | 1 | 3 |
| CXM | 11 | 16 | 2 | 7 | 12 | 8 | 10 | 15 | 4 | 6 | 9 | 14 | 13 | 5 | 1 | 3 |
| CRO | 10 | 11 | 4 | 7 | 16 | 8 | 2 | 14 | 6 | 13 | 3 | 5 | 12 | 9 | 15 | 1 |
| AMC | 9 | 10 | 3 | 14 | 6 | 11 | 7 | 12 | 15 | 4 | 8 | 13 | 1 | 5 | 16 | 2 |
| CAZ | 10 | 15 | 11 | 8 | 6 | 7 | 12 | 14 | 1 | 3 | 4 | 2 | 5 | 13 | 16 | 9 |
| CTT | 12 | 3 | 2 | 10 | 13 | 16 | 9 | 7 | 6 | 8 | 15 | 4 | 5 | 14 | 1 | 11 |
| SAM | 12 | 11 | 8 | 13 | 5 | 7 | 10 | 4 | 16 | 9 | 14 | 6 | 2 | 3 | 15 | 1 |
| CPR | 7 | 9 | 3 | 6 | 8 | 13 | 16 | 11 | 2 | 1 | 5 | 4 | 12 | 14 | 15 | 10 |
| CPD | 13 | 14 | 7 | 6 | 16 | 12 | 5 | 15 | 4 | 8 | 3 | 11 | 10 | 9 | 2 | 1 |
| TZP | 6 | 5 | 2 | 10 | 3 | 9 | 12 | 8 | 7 | 1 | 15 | 11 | 4 | 16 | 14 | 13 |
| FEP | 10 | 15 | 13 | 14 | 11 | 7 | 2 | 12 | 8 | 5 | 4 | 6 | 3 | 9 | 16 | 1 |
| Best value | 4 | 3 | 2 | 3 | 3 | 5 | 2 | 4 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 |
| Worst value | 14 | 16 | 14 | 14 | 16 | 16 | 15 | 15 | 16 | 13 | 15 | 14 | 15 | 16 | 16 | 13 |
| Median value | 10 | 11 | 7 | 7 | 9 | 8 | 7 | 12 | 6 | 6 | 4 | 6 | 5 | 9 | 15 | 2 |
Based on the strong patterns of pleiotropy we observed, we reasoned that the choice and the succession of antibiotics were at least as important as other cycling considerations. We formalized our approach to identifying optimal antibiotic treatment paths as follows.