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PQ (10 mg/kg, IP) increased, whereas APN (100 μg/kg or 500μg/kg, IV) reversed, TIMP-1 levels at 3, 7, 14and 21 d after PQ injection. TIMP-1 levels were determined by an enzyme-linked immunosorbent assay. Values represent the mean ± standard error of the mean of four parallel measurements. *P<0.05. APN, adiponectin; TIMP-1, tissue inhibitor of metalloproteinase-1; PQ, paraquat.
