Fig 10. AdipoR1-specific siRNA reversed the protective effect of APN against PQ-mediated fibrosis in lung fibroblasts WI-38 at 72 h after PQ incubation.

Cell viability, apoptosis and collagen type III mRNA expression in lung fibroblasts were measured via CCK-8 assay, Annexin V-FITC/PI staining with flow cytometry, and RT-PCR, respectively. Values represent the mean ± standard error of the mean of three parallel measurements. *P<0.05. APN, adiponectin; PQ, paraquat, AdipoR, APN receptor.