Table 5. Top altered pathways from blood following kidney transplant.

Week 1	Month 3	Month 6
Higher Levels Than at Baseline
Axonal Guidance Signaling (12)	IL-8 Signaling (6)	Antiproliferative Role of Somatostatin Receptor 2 (2)
LXR/RXR Activation (6)	Complement System (3)	Spermine and Spermidine Degradation I (1)
Airway Pathology in Chronic Obstructive Pulmonary Disease (2)	Airway Pathology in Chronic Obstructive Pulmonary Disease (2)	Melatonin Degradation II (1)
Lower Levels Than at Baseline
T Cell Receptor Signaling (18)	T Cell Receptor Signaling (16)	Granulocyte Adhesion and Diapedesis (8)
iCOS-iCOSL Signaling in T Helper Cells (17)	iCOS-iCOSL Signaling in T Helper Cells (16)	Agranulocyte Adhesion and Diapedesis (8)
CTLA4 Signaling in Cytotoxic T Lymphocytes (13)	CTLA4 Signaling in Cytotoxic T Lymphocytes (12)	Communication between Innate and Adaptive Immune Cells (6)
Higher and Lower Levels, Combined
T Cell Receptor Signaling (18)	T Cell Receptor Signaling (16)	Granulocyte Adhesion and Diapedesis (17)
iCOS-iCOSL Signaling in T Helper Cells (17)	iCOS-iCOSL Signaling in T Helper Cells (16)	Agranulocyte Adhesion and Diapedesis (14)
CTLA4 Signaling in Cytotoxic T Lymphocytes (14)	CTLA4 Signaling in Cytotoxic T Lymphocytes (12)	Macropinocytosis Signaling (8)

Top canonical gene pathways altered at week 1, months 3 and 6 compared to baseline using Ingenuity Pathway Analysis of DEGs with false discovery rate (FDR) < 0.01 and 2 or greater fold change. The number of DEGs in the pathway is shown in parentheses.

DEG = Differentially Expressed Gene.

Baseline = prior to transplant.