Table 1. Clinical profile: age, gender, MRI abnormalities, EEG activity, and location of noninvasive techniques (ESI and ASL) and invasive techniques (sEEG).

Pt	Sex	Age	Years since beginning	Seizure frequency	Hx	Current antiepileptic therapy	Standard MRI	EEG	ESI	ASL	sEEG
7	F	46	26	5–6/month	negative	VPA, LEV, ZNS	negative	sharp-waves over the frontotemporal right derivations	localization in right anterior temporal areas	hypoperfusion in right temporal and frontotemporal regions	right temporal pole focus
8	F	62	30	3–4/month	febrile convulsion	CBZ	negative	runs of fast, spiky activity over the frontotemporal right leads	localization in right temporal and frontotemporal areas	hypoperfusion in right temporal and frontotemporal regions	none
9	F	68	48	1/day	negative	CBZ, LTG	bilateral hippocampal hyperintensity	right frontotemporal spikes	localization in right temporal and frontotemporal regions	hypoperfusion in right temporal regions	none
10	M	48	30	1/day	febrile convulsion	CBZ, LEV	negative	left frontotemporal spikes	localization in left anterior temporal areas	hypoperfusion in left temporal and frontotemporal regions	none
11	M	48	18	1/week	negative	VPA, ZNS, LTG	mild bilateral hippocampal hyperintensity	rare anterior temporal spikes, with right predominance	localization in right anterior temporal areas	hypoperfusion localized to right temporal regions	none
12	F	28	2	2–3/month	familiar	CBZ, VPA	altered areas in the right lateral frontobasal lobe, left anteroinferior frontal lobe, medioposterior portion of the left hippocampus, left frontoparietal junction	left frontotemporal spikes	localization in left temporal and frontotemporal regions	hypoperfusion localized to left temporal regions	none

VPA = valproate; LEV = levetiracetam; ZNS = zonisamide; CBZ = carbamazepine; LTG = lamotrigine.