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. 2015 May 6;10(5):e0126317. doi: 10.1371/journal.pone.0126317

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Fig 3 — The regional pattern of APP_NLI expression in four distinct anatomical structures (cerebral cortex (Ctx.), hippocampus (Hpp.), olfactory bulb (Olf.), and cerebellum (Cbm.)) of brain was analyzed using mouse monoclonal antibody LN27, which specifically recognizes human APP, and 6E10. The APP transgene was expressed in cerebral cortex and hippocampus with a minor portion in olfactory bulb; however, no expression was observed in cerebellum. No immunoreactivity using these human-specific antibodies was seen in non-transgenic littermates (neg). Alpha-tubulin served as the loading control. Representative blots show the APP_NLI expression pattern of female mice, and similar results were found in male mice.