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Near-infrared fluorescence delineation of orthotopic tongue tumors. OSC-19-luc2-cGFP tongue tumors could clearly be identified after injection of the epidermal growth factor receptor-specific nanobody 7D12-800CW (50 μg) using both the Artemis and Pearl. No fluorescence could be observed after injection of 50 μg of control nanobody R2-800CW. Contrast-to-noise ratios (CNR) calculated by using the Artemis and Pearl are shown. A = Artemis; P = Pearl.
