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Mean (±SEM) percentage open arm entries (a) and percentage time spent on the open arms (b) in the EPM test in mice, 30 min after an acute injection of saline, mephedrone (0.05 mg/kg, i.p.), nicotine (0.05 mg/kg, s.c.), or mephedrone co-administered with nicotine; n = 8–10; # p < 0.05; ## p < 0.01 versus mephedrone-treated control group; ^p < 0.05 versus nicotine-treated control group; Tukey’s test
