Table 2.
Chr | rs no. | Allelesa | MAFb | Genotypes casesc | Genotypes controlsc | pgenotypic value | ptrend value | pallelic value | ORdominant (95 % CI)d; p value | ORrecessive(95 % CI)e; p value | |
---|---|---|---|---|---|---|---|---|---|---|---|
2q31 | rs2072590 | G / t | 0.35 | All | 116 / 115 / 41 | 198 / 207 / 59 | 0.633 | 0.652 | 0.686 | 1.001 (0.740–1.355); 0.995 | 1.218 (0.793–1.873); 0.368 |
Serous | 38 / 43 / 16 | 0.579 | 0.343 | 0.379 | 1.156 (0.739–1.808); 0.526 | 1.356 (0.743–2.475); 0.320 | |||||
Mucinous | 11 / 16 / 3 | 0.644 | 0.797 | 0.905 | 1.286 (0.598–2.764); 0.519 | 0.763 (0.224–2.594); 1.000f | |||||
Endometrioid | 28 / 15 / 10 | 0.067 | 0.690 | 0.762 | 0.665 (0.376–1.175) ; 0.159 | 1.596 (0.761–3.348); 0.212 | |||||
Clear cell | 9 / 11 / 6 | 0.301 | 0.183 | 0.230 | 1.406 (0.614–3.221); 0.418 | 2.059 (0.794–5.338); 0.130 | |||||
Mixed | 11 / 10 / 3 | 0.952 | 0.813 | 0.933 | 0.880 (0.386–2.005); 0.760 | 0.981 (0.284–3.390); 1.000f | |||||
Solid tumor | 7 / 9 / 1 | 0.645 | 0.750 | 0.891 | 1.063 (0.398–2.843); 0.903 | 0.429 (0.056–3.297); 0.708f | |||||
Untyped | 12 / 11 / 2 | 0.748 | 0.471 | 0.566 | 0.806 (0.360–1.806); 0.600 | 0.597 (0.137–2.598); 0.756f | |||||
3q25 | rs2665390 | c / T | 0.09 | All | 218 / 50 / 2 | 380 / 77 / 5 | 0.744 | 0.715 | 0.784 | 1.105 (0.742–1.625); 0.610 | 0.682 (0.131–3.542); 1.000f |
Serous | 75 / 20 / 1 | 0.619 | 0.389 | 0.463 | 1.298 (0.756–2.226); 0.343 | 0.962 (0.111–8.333); 1.000f | |||||
Mucinous | 27 / 3 / 0 | 0.522 | 0.255 | 0.354f | 0.515 (0.153–1.739); 0.452f | N/A | |||||
Endometrioid | 43 / 8 / 0 | 0.740 | 0.606 | 0.734 | 0.862 (0.391–1.903); 0.713 | N/A | |||||
Clear cell | 20 / 5 / 1 | 0.425 | 0.344 | 0.471 | 1.390 (0.541–3.571); 0.492 | 3.656 (0.411–32.504); 0.281f | |||||
Mixed | 17 / 7 / 0 | 0.261 | 0.240 | 0.082 | 1.908 (0.766–4.751); 0.159 | N/A | |||||
Solid tumor | 15 / 3 / 0 | 0.906 | 0.829 | 0.400f | 0.818 (0.234–2.856); 1.000f | N/A | |||||
Untyped | 21 / 4 / 0 | 0.867 | 0.740 | 0.791 | 0.883 (0.295–2.641); 1.000f | N/A | |||||
8q24 | rs10088218 | a / G | 0.12 | All | 223 / 44 / 4 | 357 / 100 / 7 | 0.214 | 0.120 | 0.137 | 0.718 (0.491–1.050); 0.086 | 0.978 (0.284–3.373); 1.000f |
Serous | 80 / 16 / 0 | 0.249 | 0.118 | 0.152 | 0.667 (0.374–1.190); 0.168 | N/A | |||||
Mucinous | 26 / 4 / 0 | 0.427 | 0.193 | 0.301f | 0.513 (0.175–1.504); 0.265f | N/A | |||||
Endometrioid | 42 / 11 / 0 | 0.655 | 0.566 | 0.679 | 0.874 (0.435–1.757); 0.705 | N/A | |||||
Clear cell | 21 / 4 / 1 | 0.519 | 0.874 | 0.873 | 0.794 (0.293–2.158); 0.812f | 2.611 (0.309–22.066); 0.356f | |||||
Mixed | 19 / 3 / 2 | 0.036 | 0.642 | 0.805 | 0.878 (0.320–2.408); 1.000f | 5.935 (1.164–30.263); 0.068f | |||||
Solid tumor | 15 / 2 / 0 | 0.531 | 0.260 | 0.418f | 0.445 (0.100–1.977); 0.383f | N/A | |||||
Untyped | 20 / 4 / 1 | 0.529 | 0.953 | 0.952 | 0.834 (0.306–2.276); 1.000f | 2.720 (0.321–23.020); 0.345 | |||||
8q24 | rs10098821 | C / t | 0.11 | All | 233 / 34 / 3 | 363 / 94 / 6 | 0.028 | 0.014 | 0.016 | 0.576 (0.382–0.870); 0.008 | 0.856 (0.212–3.451); 1.000f |
Serous | 84 / 12 / 0 | 0.099 | 0.033 | 0.045 | 0.519 (0.272–0.988); 0.043 | N/A | |||||
Mucinous | 25 / 4 / 0 | 0.558 | 0.285 | 0.390f | 0.581 (0.196–1.708); 0.481f | N/A | |||||
Endometrioid | 44 / 9 / 0 | 0.583 | 0.358 | 0.451 | 0.743 (0.351–1.576); 0.435f | N/A | |||||
Clear cell | 25 / 1 / 0 | 0.093 | 0.033 | 0.036f | 0.145 (0.019–1.085); 0.025f | N/A | |||||
Mixed | 19 / 3 / 2 | 0.023 | 0.514 | 0.667 | 0.955 (0.348–2.623); 1.000f | 6.924 (1.321–36.304); 0.054f | |||||
Solid tumor | 16 / 1 / 0 | 0.293 | 0.122 | 0.165f | 0.227 (0.030–1.732); 0.141f | NA | |||||
Untyped | 20 / 4 / 1 | 0.488 | 0.905 | 0.905 | 0.908 (0.332–2.479); 1.000f | 3.174 (0.367–27.435); 0.310f | |||||
9p22 | rs3814113 | c / T | 0.41 | All | 123 / 114 / 35 | 167 / 213 / 82 | 0.033 | 0.010 | 0.009 | 0.696 (0.505–0.930); 0.015 | 0.684 (0.446–1.050); 0.081 |
Serous | 50 / 36 / 11 | 0.016 | 0.006 | 0.006 | 0.532 (0.342–0.827); 0.005 | 0.593 (0.303–1.160); 0.123 | |||||
Mucinous | 12 / 12 / 6 | 0.809 | 0.905 | 0.903 | 0.849 (0.399–1.806); 0.671 | 1.159 (0.459–2.925); 0.755 | |||||
Endometrioid | 19 / 24 / 9 | 0.996 | 0.936 | 0.935 | 0.983 (0.542–1.784); 0.956 | 0.970 (0.455–2.068); 0.937 | |||||
Clear cell | 12 / 11 / 3 | 0.524 | 0.257 | 0.310 | 0.661 (0.299–1.461); 0.303 | 0.605 (0.177–2/062); 0.596f | |||||
Mixed | 9 / 12 / 3 | 0.800 | 0.656 | 0.762 | 0.944 (0.404–2.203); 0.893 | 0.662 (0.193–2.272); 0.782f | |||||
Solid tumor | 10 / 7 / 1 | 0.178 | 0.064 | 0.085 | 0.453 (0.175–1.170); 0.094 | 0.273 (0.036–2.078); 0.335f | |||||
Untyped | 11 / 12 / 2 | 0.422 | 0.226 | 0.277 | 0.721 (0.320–1.623); 0.427 | 0.403 (0.093–1.744); 0.282f | |||||
17q21 | rs9303542 | A / g | 0.25 | All | 134 / 123 / 15 | 261 / 175 / 28 | 0.134 | 0.162 | 0.193 | 1.324 (0.981–1.788); 0.067 | 0.909 (0.476–1.734); 0.772 |
Serous | 54 / 36 / 6 | 0.997 | 0.975 | 0.975 | 1.000 (0.642–1.558); 1.000 | 1.038 (0.418–2.581); 0.936 | |||||
Mucinous | 17 / 12 / 1 | 0.823 | 0.785 | 0.907 | 0.983 (0.467–2.072); 0.964 | 0.537 (0.071–4.089); 1.000f | |||||
Endometrioid | 24 / 26 / 3 | 0.270 | 0.230 | 0.285 | 1.554 (0.876–2.751); 0.128 | 0.934 (0.274–3.185); 1.000f | |||||
Clear cell | 12 / 11 / 3 | 0.414 | 0.207 | 0.274 | 1.500 (0.679–3.314); 0.313 | 2.031 (0.575–7.179); 0.222f | |||||
Mixed | 9 / 15 / 0 | 0.039 | 0.315 | 0.413 | 2.143 (0.919–4.997); 0.072 | N/A | |||||
Solid tumor | 9 / 9 / 0 | 0.388 | 0.988 | 0.988 | 1.286 (0.501–3.299); 0.600 | N/A | |||||
Untyped | 9 / 14 / 2 | 0.138 | 0.076 | 0.112 | 2.286 (0.990–5.280); 0.047 | 1.354 (0.304–6.038); 0.660f | |||||
19p13 | rs2363956 | G / t | 0.49 | All | 56 / 154 / 62 | 115 / 244 / 105 | 0.196 | 0.399 | 0.451 | 1.271 (0.885–1.825); 0.193 | 1.009 (0.706–1.443); 0.959 |
Serous | 17 / 53 / 26 | 0.235 | 0.139 | 0.169 | 1.531 (0.870–2.694); 0.137 | 1.270 (0.770–2.094); 0.348 | |||||
Mucinous | 7 / 18 / 5 | 0.559 | 0.738 | 0.837 | 1.083 (0.453–2.590); 0.858 | 0.684 (0.255–1.831); 0.650f | |||||
Endometrioid | 13 / 28 / 12 | 0.948 | 0.971 | 0.979 | 1.104 (0.524–1.962); 0.967 | 1.001 (0.507–1.974); 0.998 | |||||
Clear cell | 8 / 11 / 7 | 0.719 | 0.911 | 0.906 | 0.741 (0.314–1.751); 0.493 | 1.260 (0.515–3.079); 0.612 | |||||
Mixed | 6 / 17 / 1 | 0.059 | 0.203 | 0.265 | 0.989 (0.383–2.551); 0.981 | 0.149 (0.020–1.114); 0.039f | |||||
Solid tumor | 1 / 12 / 5 | 0.145 | 0.146 | 0.206 | 5.602 (0.737–42.578); 0.088f | 1.315 (0.458–3.774); 0.574f | |||||
Untyped | 4 / 15 / 6 | 0.512 | 0.476 | 0.579 | 1.730 (0.582–5.146); 0.473f | 1.080 (0.420–2.774); 0.873 |
N/A not applicable
Statistically significant results for dominan and recessive model are highlighted in bold (p < 0.00714)
aUppercase denotes the more frequent allele in the control samples
bMAF, minor allele frequency calculated from the control samples
cThe order of genotypes: DD / Dd / dd (d is the minor allele in the control samples)
dDominant model: dd + Dd vs DD (d is the minor allele)
eRecessive model: dd vs Dd + DD (d is the minor allele)
fFisher exact test