. 2014 Dec 12;32(6):1975–1992. doi: 10.1007/s11095-014-1591-0

Table II.

Metabolic Reactions and the Basal Steady State Values Computed for State Variables. See Appendix B for More MITOsym®equation Descriptions

	State variable	Differential equation for hepatica bioenergetics reactions	Basal SS value for glucose media	Basal SS value for galactose media
s1	[drug_cellular]	$\frac{d {[drug]}_{cellular}}{d t} = Flu x_{uptake}^{drug} - Flu x_{cellular}^{drug}$	0 [mM]	0 [mM]
s2	[G6P]	$\frac{d [G 6 P]}{d t} = Eff_Flu x_{prod}^{G 6 P} - Eff_Flu x_{prod, cellular}^{p y r} * 0.5 - Flu x_{prod}^{g l y} + Flu x_{degrad}^{g l y}$	1 [mM]	1 [mM]
s3	[Glycogen]	$\frac{d [Glycogen]}{d t} = Flu x_{prod}^{g l y} - Flu x_{degrad}^{g l y}$	0.001 [mM]	0 [mM]
s4	[Pyruvate_cellular]	$\frac{d [P y r_{cellular}]}{d t} = Eff_Flu x_{prod, cellular}^{p y r} - Eff_Flu x_{prod, mito}^{p y r} - Flu x_{prod}^{lac}$	5 [mM]	4.7 [mM]
s5	[Pyruvate_mito]	$\frac{d {[P y r]}_{mito}}{d t} = Eff_Flu x_{prod, mito}^{p y r} - Eff_Flu x_{prod}^{p y r 2 OX}$	5 [mM]	4.7 [mM]
s6	[OX_mito]	$\frac{d {[OX]}_{mito}}{d t} = Eff_Flu x_{prod}^{p y r 2 OX} - Eff_Flu x_{prod}^{E T C}$	0.3 [mM]	0.4 [mM]
s7	ΔΨ _m	$\frac{d Ψ_{m}}{d t} = C o n v e r s i o n_{f} \times E f f_F l u x_{p r o d}^{E T C} - E f f_F l u x_{p r o d, m i t o}^{A T P} - U n c o u p l i n g_{d r u g}$	172.2 [mM]	169.4 [mM]
s8	[ATP_cellular]	$\frac{d {[A T P]}_{cellular}}{d t} = Eff_Flu x_{mito, lowgrad}^{A T P} + Eff_Flu x_{g l y}^{A T P} - k * {[A T P]}_{cellular}$	4 [mM]	4 [mM]