Table V.

Bioenergetic Parameters and Properties Simulated in Various Conditions

		Basal value (Glucose)	Basal value (Galactose)	Rotonone 0.5 uM	FCCP 3 uM	Oligomycin 1 uM
		5.5 mM 1 mM
Intermediates
G6P	[mM]	1.0	0.13	1.0	0.96	0.87	0.98
Pyruvatecellular	[mM]	5.0	4.64	4.7	7.91	4.95	6.95
Pyruvatemito	[mM]	5.0	4.89	4.7	8.12	4.11	6.70
ATPcellular	[mM]	4.0	3.95	3.88	1.97	3.41	NA
ΔΨ m		172.2	172.2	169.4	37.4	124.0	184.3
Calculated flux
Eff _ Flux G6Pprod	[mM/min]	1.87	1.76	2.13	2.56	4.19	2.35
Eff _ Flux pyrprod, cellular	[mM/min]	3.75	3.53	4.26	5.18	8.38	4.69
Eff _ Flux lacprod	[mM/min]	3.15	2.92	3.45	4.98	5.96	4.38
Eff _ Flux pyrprod, mito	[mM/min]	0. 6	0. 6	0.84	0.19	2.42	0.31
Eff _ Flux pyr2OXprod	[mM/min]	0. 6	0. 6	0.84	0.19	2.42	0.31
Eff _ Flux ETCprod	[mM/min]	0. 6	0. 6	0.84	0.19	2.42	0.31
Eff _ Flux ATPmito,lowgradient	[pmol ATP/min]	1000	999.6	1334.7	259.7	711.1	NA
Eff _ Flux ATPprod,gly	[pmol ATP/min]	337.2	320.3	0	403.1	430.8	NA
Pathway signal (normalized)
${\mathrm{S}}_{{\mathrm{f}\mathrm{b}}_{\mathrm{H}\_\mathrm{Gradient}}}$		1	1.02	1.38	4.17	4.17	0.19
${\mathrm{S}}_{{\mathrm{f}\mathrm{b}}_{\mathrm{G}6\mathrm{P}2\mathrm{G}\mathrm{l}\mathrm{u}}}$		1	3.40	1.14	1.38	2.24	1.24
${\mathrm{S}}_{{\mathrm{f}\mathrm{b}}_{\mathrm{A}\mathrm{T}\mathrm{P}2\mathrm{g}\mathrm{l}\mathrm{y}}}$		1	1	1.00	1.08	1.02	1.06
${\mathrm{S}}_{{\mathrm{f}\mathrm{b}}_{\mathrm{E}\mathrm{T}\mathrm{C}2\mathrm{g}\mathrm{l}\mathrm{y}}}$		1	1	1.15	1.28	2.21	1.19
${\mathrm{S}}_{{\mathrm{f}\mathrm{b}}_{\mathrm{mitoPyr}}}$		1	1.07	1.19	0.23	1.8	0.42
${\mathrm{S}}_{{\mathrm{f}\mathrm{b}}_{\mathrm{mitoOX}}}$		1	1.07	1	0.07	1	2.56
${\mathrm{S}}_{{\mathrm{f}\mathrm{b}}_{\mathrm{M}\mathrm{M}\mathrm{P}2\mathrm{A}\mathrm{T}\mathrm{P}}}$		1	1	0.97	0.88	0.92	1
${\mathrm{S}}_{{\mathrm{Eff}}_{\mathrm{glycolysis}}}$		1	0.99	NA	0.89	0.63	1
S fb _ ATP2mitoATP _ prod		1	1	1.4	1.18	1.05	1