Table 3.

Cycle-Specific and Cumulative Fecundability for hCG Detected and Clinically Confirmed Pregnancy (n = 1214 Women)^a

Cycle	Overall				Original				Expanded
	LDA n = 608		Placebo n = 606		LDA n = 272		Placebo n = 269		LDA n = 336		Placebo n = 337
	Cycle-Specific	Cumulative	Cycle-Specific	Cumulative	Cycle-Specific	Cumulative	Cycle-Specific	Cumulative	Cycle-Specific	Cumulative	Cycle-Specific	Cumulative
hCG detected pregnancy (n = 792)
1	23.5	23.5	21.3	21.3	24.3	24.3	25.3	25.3	22.9	22.9	18.1	18.1
2	15.5	39.0	17.3	38.5	18.5	42.7	14.2	39.5	13.0	35.9	19.7	37.8
3	13.6	52.6	10.8	49.3	16.4	59.1	9.7	49.3	11.2	47.2	11.6	49.5
4	7.7	60.3	9.1	58.4	6.8	65.9	8.4	57.7	8.5	55.7	9.6	59.1
5	6.5	66.9	5.5	63.9	5.3	71.2	5.7	63.5	7.6	63.2	5.2	64.3
6	6.1	73.0	3.2	67.1	5.8	77.1	3.4	66.8	6.2	69.5	3.1	67.5
Pb				0.11				0.03				0.79
Clinically confirmed pregnancy (n = 728)
1	20.4	20.4	18.3	18.3	22.1	22.1	22.7	22.7	19.0	19.0	14.8	14.8
2	15.0	35.4	16.4	34.7	18.2	40.2	13.1	35.8	12.4	31.4	19.2	34.0
3	12.7	48.0	10.1	44.9	15.1	55.4	9.0	44.8	10.6	42.0	11.1	45.1
4	7.0	55.0	9.4	54.3	5.1	60.5	8.9	53.7	8.6	50.6	9.8	55.0
5	7.0	62.0	4.45	58.8	6.2	66.7	4.6	58.3	7.6	58.2	4.3	59.3
6	5.5	67.5	3.3	62.1	5.5	72.2	3.8	62.1	5.5	63.8	2.9	62.2
Pb				0.13				0.04				0.92

Women were block randomized into two strata based on eligibility criteria at enrollment: original, women with exactly one prior pregnancy loss <20 weeks' gestation, which occurred in the 12 months preceding enrollment; expanded, women with one or two prior pregnancy losses of any gestational age occurring any time prior to enrollment.

^aAmong 1228 participants, there were 14 withdrawals whose last visit day was at randomization and thus were excluded from the time to pregnancy analyses.

^bP value represents LDA vs placebo, log rank test of cumulative pregnancy rate.