Table 1.
HIV-1 RT and M. tuberculosis inhibition by Julianaceae and Clusiaceae extracts∗ and their cytotoxicity to THP-1 human cell line.
| Species | Location/voucher | Part used/gender | % inhibition of HIV-1 RT |
% inhibition of M. tuberculosis |
% cytotoxicity |
|---|---|---|---|---|---|
| Julianaceae | |||||
| Amphipterygium amplifolia | Jalisco/15637 | Stem bark/M | 24.8 ± 2.1 | 90.1 ± 0.6 | 14.0 ± 1.8 |
| Leaf/M | 18.7 ± 3.2 | 89.8 ± 0.1 | 16.3 ± 2.3 | ||
| Jalisco/15638 | Stem bark/F | 36.7 ± 2.8 | 89.1 ± 0.4 | 23.3 ± 1.7 | |
| Leaf/F | 46.5 ± 4.8 | 89.7 ± 0.2 | 25.5 ± 1.9 | ||
| Amphipterygium molle | Jalisco/15639 | Stem bark/M | 19.3 ± 2.2 | 89.6 ± 0.5 | 19.7 ± 1.0 |
| Jalisco/15640 | Stem bark/F | 11.3 ± 0.7 | 88.7 ± 0.7 | 12.5 ± 1.2 | |
| Leaf/F | 49.8 ± 1.8 | 89.0 ± 0.6 | 19.5 ± 1.5 | ||
| Amphipterygium adstringens | Jalisco/15641 | Stem bark/M | 9.2 ± 2.7 | 88.2 ± 0.1 | 18.4 ± 1.5 |
| Leaf/M | 6.1 ± 0.7 | 90.2 ± 0.7 | 25.1 ± 1.9 | ||
| Amphipterygium glaucum | Michoacán/15644 | Stem bark/M | 40.0 ± 2.0 | 86.9 ± 0.5 | 22.9 ± 1.6 |
| Leaf/M | 48.5 ± 0.7 | 89.6 ± 0.9 | 10.9 ± 1.6 | ||
| Michoacán/15645 | Stem bark/F | 21.7 ± 2.1 | 84.6 ± 1.3 | 19.7 ± 1.3 | |
| Amphipterygium simplicifolium | Oaxaca/16125 | Stem bark/ | 44.3 ± 1.2 | 90.3 ± 0.2 | 9.2 ± 1.5 |
| Leaf/ | 7.9 ± 0.4 | 90.5 ± 1.0 | 19.5 ± 0.3 | ||
| Clusiaceae | |||||
| Vismia mexicana | Veracruz/134793§ | Leaf | 43.7 ± 0.7 | 63.5 ± 1.1 | 10.6 ± 1.4 |
| Vismia baccifera | Oaxaca/134792§ | Leaf | 54.0 ± 0.8 | 70.3 ± 0.5 | 10.7 ± 1.7 |
| Clusia guatemalensis | Oaxaca/134795§ | Leaf | 30.5 ± 2.4 | 62.1 ± 0.7 | 17.1 ± 1.3 |
| Clusia lundellii | Oaxaca/136723§ | Leaf | 27.3 ± 1.1 | 58.3 ± 0.4 | 18.3 ± 1.4 |
| Calophyllum brasiliense | Veracruz/15526 | Leaf | 67.6 ± 1.2 | 82.8 ± 0.4 | 23.8 ± 1.1 |
∗CH2Cl2–MeOH extracts tested at 50 μg/mL. M = male, F = female. Vouchers at IMSSM or FCME§.